Two American college students on a walking tour of Britain are attacked by a werewolf that none of the locals will admit exists.

Based on the true story of the famous murderers, this movie follows the hapless exploits of William Burke (Simon Pegg) and William Hare (Andy Serkis) as they fall into the highly-profitable business of providing cadavers for the medical fraternity in 19th-century Edinburgh, Scotland, then the center of medical learning. The one thing they were short of was bodies.