In 2035, techno-phobic homicide detective Del Spooner of the Chicago PD heads the investigation of the apparent suicide of leading robotics scientist, Dr. Alfred Lanning. Unconvinced of the motive, Spooner's investigation into Lanning's death reveals a trail of secrets and agendas within the USR (United States Robotics) corporation and suspicions of murder. Little does he know that his investigation would lead to uncovering a larger threat to humanity.

A poetic guitarist Eric Draven is brought back to life by a crow a year after he and his fiancée are murdered. The crow guides him through the land of the living, and leads him to his killers: knife thrower Tin-tin, drugetic Funboy, car buff T-Bird, and the unsophisticated Skank. One by one, Eric gives these thugs a taste of their own medicine. However their leader Top-Dollar, a world-class crime lord who will dispatch his enemies with a Japanese sword and joke about it later, will soon learn the legend of the crow and the secret to the vigilante's invincibility.