A priest from the Vatican is sent to Sao Paulo, Brazil to investigate the appearance of the face of the Virgin Mary on the side of a building. While there he hears of a statue of the Virgin Mary bleeding tears in a small town outside of the city. Meanwhile, a young woman in the U.S. begins to show signs of stigmata, the wounds of Christ. The priest from the Vatican links up with her and cares for her as she is increasingly afflicted by the stigmata. Her ranting and raving finally begins to make sense to the priest who starts to question what his religion has stood for for the last 1900 years.

The inhabitants of Antonio Island, off the coast of Oregon, are about to unveil a statue honoring the four men (Castle, Wayne, Williams and Malone) who founded their town in 1871. Nick Castle is one of the descendants of the men, and owns a fishing charter company, using his vessel, the Seagrass, for tourism. When his girlfriend Elizabeth Williams returns to the island after spending six months in New York, a bizarre series of events begin to occur, including several gruesome deaths and the presence of a mysterious fog. When Elizabeth slips in Nick's boathouse and falls into the sea, she finds an old journal from 1871, written by Patrick Malone, one of the town's founders. It tells how a man named Blake bought half the island for use as a leper colony. While bringing his people to Antonio Island in their clipper ship, the Elizabeth Dane, Blake is betrayed by Castle, Wayne, Williams and Malone. The four men locked Blake and his people in the vessel, stole their money and possessions, and then set fire to the ship, killing everyone aboard. In the present day, the ghosts of Blake and his crew have risen from their watery grave to seeking revenge on the descendants of the four men.