Lisbeth is recovering in a hospital and awaiting trial for three murders when she is released. Mikael must prove her innocence, but Lisbeth must be willing to share the details of her sordid experiences with the court.

As computer hacker Lisbeth and journalist Mikael investigate a sex-trafficking ring, Lisbeth is accused of three murders, causing her to go on the run while Mikael works to clear her name.

Forty years ago, Harriet Vanger disappeared from a family gathering on the island owned and inhabited by the powerful Vanger clan. Her body was never found, yet her uncle suspects murder and that the killer is a member of his own tightly knit but dysfunctional family. He employs disgraced financial journalist Mikael Blomkvist and the tattooed, ruthless computer hacker Lisbeth Salander to investigate. When the pair link Harriet's disappearance to a number of grotesque murders from almost forty years ago, they begin to unravel a dark and appalling family history; but, the Vangers are a secretive clan, and Blomkvist and Salander are about to find out just how far they are prepared to go to protect themselves.