Six astronauts aboard the space station study a sample collected from Mars that could provide evidence for extraterrestrial life on the Red Planet. The crew determines that the sample contains a large, single-celled organism - the first example of life beyond Earth. But..things aren't always what they seem. As the crew begins to conduct research, and their methods end up having unintended consequences, the life form proves more intelligent than anyone ever expected.

Matt Weston (Ryan Reynolds) is a CIA rookie who is manning a safe house in Cape Town, South Africa, when Tobin Frost (Denzel Washington) the CIA's most wanted rogue agent is captured and taken to the safe house. During Frost's interrogation, the safe house is overtaken by mercenaries who want Frost. Weston and Frost escape and must stay out of the gunmen's sight until they can get to another safe house.